pkpd.protocols.protocol_pkpd_dissolution_wagner_nelson module¶

class pkpd.protocols.protocol_pkpd_dissolution_wagner_nelson.ProtPKPDDeconvolutionWagnerNelson(**kwargs)[source]¶

Bases: pkpd.protocols.protocol_pkpd.ProtPKPD

Calculate the absorption profile of an in vivo concentration profile using the Wagner-Nelson approach. This is only valid for profiles that have been modelled with a monocompartment PK model.

The formula is Fabs(t)=(Cp(t)+Ke*AUC0t(t))/(Ke*AUC0inf) where Ke=Cl/V

In this implementation it is assumed that AUC0inf is the last AUC0t observed, meaning that Cp(t) has almost vanished in the last samples

ANOTHER_INPUT = 1¶

BIOAVAIL_DIV = 2¶

BIOAVAIL_MULT = 1¶

BIOAVAIL_NONE = 0¶

SAME_INPUT = 0¶

addSample(sampleName, t, y)[source]¶

createOutputStep()[source]¶

deconvolve(objId1)[source]¶

estimateAUCrightTail(t, Cp, Cl, V)[source]¶