Source code for xmipp3.protocols.protocol_ctf_micrographs

# **************************************************************************
# *
# * Authors:     Carlos Oscar S. Sorzano (coss@cnb.csic.es)
# *              Amaya Jimenez (ajimenez@cnb.csic.es)
# *              Javier Mota Garcia (jmota@cnb.csic.es)
# *
# * Unidad de  Bioinformatica of Centro Nacional de Biotecnologia , CSIC
# *
# * This program is free software; you can redistribute it and/or modify
# * it under the terms of the GNU General Public License as published by
# * the Free Software Foundation; either version 2 of the License, or
# * (at your option) any later version.
# *
# * This program is distributed in the hope that it will be useful,
# * but WITHOUT ANY WARRANTY; without even the implied warranty of
# * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
# * GNU General Public License for more details.
# *
# * You should have received a copy of the GNU General Public License
# * along with this program; if not, write to the Free Software
# * Foundation, Inc., 59 Temple Place, Suite 330, Boston, MA
# * 02111-1307  USA
# *
# *  All comments concerning this program package may be sent to the
# *  e-mail address 'scipion@cnb.csic.es'
# *
# **************************************************************************

import sys
import os

from pwem import RELATION_CTF
from pwem.emlib.image import ImageHandler
from pwem.objects import SetOfCTF, OrderedDict
from pyworkflow.object import String

import pyworkflow.protocol.params as params
import pyworkflow.protocol.constants as pwconst
import pyworkflow.utils as pwutils

from pwem.protocols import ProtCTFMicrographs
import pwem.emlib.metadata as md

from xmipp3.base import isMdEmpty
from xmipp3.convert import readCTFModel

from pwem.emlib import Image

[docs]class XmippProtCTFMicrographs(ProtCTFMicrographs): """ Protocol to estimate CTF on a set of micrographs using Xmipp. """ _label = 'ctf estimation' _criterion_psd = ("ctfCritIceness>1.03") _criterion_estimation = ("ctfCritFirstZero<5 OR " "ctfCritMaxFreq>20 OR " "ctfCritfirstZeroRatio<0.9 OR " "ctfCritfirstZeroRatio>1.1 OR " "ctfCritFirstMinFirstZeroRatio>10 OR " "ctfCritCorr13<0.27 OR " "ctfCritCtfMargin<1 OR " "ctfCritNonAstigmaticValidty<0 OR " "ctfCritNonAstigmaticValidty>6.5 OR " "ctfCritPsdCorr90<0.1") #"OR ctfBgGaussianSigmaU<1000") _criterion_phaseplate = ("ctfCritFirstZero<5 OR " "ctfCritMaxFreq>20 OR " "(ctfCritFirstMinFirstZeroRatio>50 AND " "ctfCritFirstMinFirstZeroRatio!=1000) OR " "ctfCritfirstZeroRatio<0.9 OR " "ctfCritfirstZeroRatio>1.1 OR " "ctfCritNonAstigmaticValidty<=0 OR " "ctfVPPphaseshift>140 OR " "ctfCritNonAstigmaticValidty>25") #ctfCritCorr13==0 OR "ctfCritFirstMinFirstZeroRatio>50 AND " _targetSamplingList = [1.75, 2.75] def __init__(self, **args): ProtCTFMicrographs.__init__(self, **args) def _createFilenameTemplates(self): prefix = '%(root)s/%(micBase)s_xmipp_ctf' _templateDict = { # This templates are relative to a micDir 'micrographs': 'micrographs.xmd', 'prefix': prefix, 'ctfParam': prefix + '.ctfparam', 'ctfErrorParam': prefix + '_error.xmd', 'psd': prefix + '.psd', 'enhanced_psd': prefix + '_enhanced_psd.xmp', 'ctfmodel_quadrant': prefix + '_ctfmodel_quadrant.xmp', 'ctfmodel_halfplane': prefix + '_ctfmodel_halfplane.xmp', 'ctf': prefix + '.xmd', 'rejected': prefix + '_rejected.xmd' } self._updateFilenamesDict(_templateDict) def _defineProcessParams(self, form): # Change default value for Automatic downsampling param = form.getParam("AutoDownsampling") param.setDefault(True) form.addParam('doInitialCTF', params.BooleanParam, default=False, label="Use defoci from a previous CTF estimation") form.addParam('ctfRelations',params.RelationParam, allowsNull=True, condition='doInitialCTF', relationName=RELATION_CTF, attributeName='inputMicrographs', label='Previous CTF estimation', help='Choose some CTF estimation related to input ' 'micrographs, in case you want to use the defocus ' 'values found previously') form.addParam('doOptimizeDefocus', params.BooleanParam, default=True, condition='doInitialCTF', label="Optimize defocus", help='If set to False, then the previous defocus is taken') form.addParam('findPhaseShift', params.BooleanParam, default=False, label="Find additional phase shift?", help='If the data was collected with phase plate, this ' 'will find additional phase shift due to phase ' 'plate', expertLevel=params.LEVEL_ADVANCED) form.addParam('doCTFAutoDownsampling', params.BooleanParam, default=True, label="Automatic CTF downsampling detection", expertLevel=pwconst.LEVEL_ADVANCED, help='If this option is chosen, the algorithm ' 'automatically tries by default the suggested ' 'Downsample factor; and if it fails, +1; ' 'and if it fails, -1.') form.addParam('refineAmplitudeContrast', params.BooleanParam, default=False, label='Allow amplitude constrast refinement', help = 'The amplitude contrast is normally kept fixed, but in ' 'some experiments it has been found that refining it ' 'might result in some improvement in the final FSC. ' 'This is not a standard practice, and should be used with caution') form.addParam('skipBorders', params.BooleanParam, default=False, expertLevel=pwconst.LEVEL_ADVANCED, help='Remove the borders of the micrograph. ' 'If True, two times the window size will be cropped.', label='Skip borders')
[docs] def getInputMicrographs(self): return self.inputMicrographs.get()
# --------------------------- STEPS functions ------------------------------ def _loadSet(self, inputSet, SetClass, getKeyFunc): """ method overrided in order to check if the previous CTF estimation is ready when doInitialCTF=True and streaming is activated """ setFn = inputSet.getFileName() self.debug("Loading input db: %s" % setFn) updatedSet = SetClass(filename=setFn) updatedSet.loadAllProperties() streamClosed = updatedSet.isStreamClosed() initCtfCheck = lambda idItem: True if self.doInitialCTF.get(): ctfSet = SetOfCTF(filename=self.ctfRelations.get().getFileName()) ctfSet.loadAllProperties() streamClosed = streamClosed and ctfSet.isStreamClosed() if not streamClosed: initCtfCheck = lambda idItem: idItem in ctfSet newItemDict = OrderedDict() for item in updatedSet: micKey = item.getObjId() # getKeyFunc(item) if micKey not in self.micDict and initCtfCheck(micKey): newItemDict[micKey] = item.clone() updatedSet.close() self.debug("Closed db.") return newItemDict, streamClosed
[docs] def calculateAutodownsampling(self,samplingRate, targetSampling): ctfDownFactor = targetSampling / samplingRate if ctfDownFactor < 1.0: ctfDownFactor = 1.0 return ctfDownFactor
def _calculateDownsampleList(self, samplingRate): downsampleList = [] if self.AutoDownsampling: ctfDownFactor = self.calculateAutodownsampling(samplingRate, self._targetSamplingList[0]) downsampleList.append(ctfDownFactor) else: ctfDownFactor = self.ctfDownFactor.get() downsampleList = [ctfDownFactor] return downsampleList if self.doCTFAutoDownsampling: downsampleList.append(self.calculateAutodownsampling(samplingRate, self._targetSamplingList[1])) downsampleList.append(1.0) return downsampleList def _estimateCTF(self, mic, *args): """ Run the estimate CTF program """ micFn = mic.getFileName() micName = mic.getMicName() micBase = self._getMicBase(mic) micDir = self._getMicrographDir(mic) localParams = self.__params.copy() localParams['pieceDim'] = self.windowSize.get() localParams['ctfmodelSize'] = self.windowSize.get() if self.doInitialCTF: # getting prevValues (in streaming couldn't be defined yet) prevValues = (self.ctfDict[micName] if micName in self.ctfDict else self.getSinglePreviousParameters(mic.getObjId())) localParams['defocusU'], localParams['defocusV'], localParams['defocusAngle'], localParams['phaseShift0'] = \ prevValues localParams['defocus_range'] = 0.1 * localParams['defocusU'] else: ma = self._params['maxDefocus'] mi = self._params['minDefocus'] localParams['defocusU'] = (ma + mi) / 2 localParams['defocus_range'] = (ma - mi) / 2 if self.findPhaseShift: localParams['phaseShift0'] = self._params['phaseShift0'] # Create micrograph dir under extra directory pwutils.path.makePath(micDir) if not os.path.exists(micDir): raise Exception("No created dir: %s " % micDir) finalName = micFn def _getFn(key): return self._getFileName(key, micBase=micBase, root=micDir) localParams['root'] = _getFn('prefix') downsampleList = self._calculateDownsampleList(mic.getSamplingRate()) try: for i, downFactor in enumerate(downsampleList): # Downsample if necessary if downFactor != 1: # Replace extension by 'mrc' cause there are some formats that # cannot be written (such as dm3) baseFn = pwutils.replaceBaseExt(micFn, 'mrc') finalName = os.path.join(micDir, baseFn) if downFactor>1: self.runJob("xmipp_transform_downsample", "-i %s -o %s --step %f --method fourier" % (micFn, finalName, downFactor)) else: self.runJob("xmipp_image_resize", "-i %s -o %s --factor %f --interp linear" % (micFn, finalName, 1.0/downFactor)) psd = Image(finalName) psd = psd.getData() if min(psd.shape) < self.windowSize.get(): localParams['pieceDim'] = self.windowSize.get()/2 localParams['ctfmodelSize'] = self.windowSize.get()/2 # Update _params dictionary with mic and micDir localParams['micFn'] = finalName localParams['samplingRate'] = mic.getSamplingRate() * downFactor # CTF estimation with Xmipp params = self._args % localParams params += " --downSamplingPerformed %f" % downFactor if not self.doInitialCTF: params += " --selfEstimation " else: if not self.doOptimizeDefocus: params += " --noDefocus --defocusV %(defocusV)f --azimuthal_angle %(defocusAngle)f" %\ localParams if not self.skipBorders.get(): params += " --skipBorders 0" self.runJob(self._program, params) # Check the quality of the estimation and reject it necessary good = self.evaluateSingleMicrograph(mic) if good: break for key in ['ctfParam', 'psd', 'enhanced_psd', 'ctfmodel_halfplane', 'ctfmodel_quadrant', 'ctf']: pwutils.moveFile(_getFn(key), self._getExtraPath()) except Exception as ex: sys.stderr.write("xmipp_ctf_estimate_from_micrograph has " \ "failed with micrograph %s" % finalName) def _createOutputStep(self): pass # --------------------------- INFO functions ------------------------------- def _validate(self): validateMsgs = [] # downsampling factor must be greater than 1 if self.ctfDownFactor.get() < 1: validateMsgs.append('Downsampling factor must be >=1.') if self.doInitialCTF: if not self.ctfRelations.hasValue() or self.ctfRelations.get() is None: validateMsgs.append('If you want to use a previous estimation ' 'of the CTF, the corresponding set of CTFs ' 'is needed') def _summary(self): summary = ProtCTFMicrographs._summary(self) if self.methodsVar.hasValue(): summary.append(self.methodsVar.get()) return summary def _methods(self): strMsg = "We calculated the CTF of micrographs %s using Xmipp " \ "[Sorzano2007a]" % self.getObjectTag('inputMicrographs') strMsg += "." if self.methodsVar.hasValue(): strMsg += " " + self.methodsVar.get() if self.hasAttribute('outputCTF'): strMsg += '\nOutput set is %s.' % self.getObjectTag('outputCTF') return [strMsg] def _citations(self): papers = ['Sorzano2007a'] return papers # --------------------------- UTILS functions ------------------------------ def _prepareArgs(self, params): self._args = ("--micrograph %(micFn)s --oroot %(root)s " "--sampling_rate %(samplingRate)s --defocusU %(" "defocusU)f --defocus_range %(defocus_range)f " "--overlap 0.7 --pieceDim %(pieceDim)s " "--ctfmodelSize %(ctfmodelSize)s --acceleration1D ") if self.findPhaseShift: self._args += "--phase_shift %(phaseShift0)f --VPP_radius 0.005" if self.refineAmplitudeContrast: self._args += "--refine_amplitude_contrast" for par, val in params.items(): self._args += " --%s %s" % (par, str(val))
[docs] def getPreviousValues(self, ctf): phaseShift0 = 0.0 if self.findPhaseShift: if ctf.hasPhaseShift(): phaseShift0 = ctf.getPhaseShift() else: phaseShift0 = 1.57079 # pi/2 ctfValues = (ctf.getDefocusU(), ctf.getDefocusV(), ctf.getDefocusAngle(), phaseShift0) else: ctfValues = (ctf.getDefocusU(), ctf.getDefocusV(), ctf.getDefocusAngle(), phaseShift0) return ctfValues
[docs] def getSinglePreviousParameters(self, micId): if self.ctfRelations.hasValue(): ctf = self.ctfRelations.get()[micId] return self.getPreviousValues(ctf)
[docs] def getPreviousParameters(self): if self.ctfRelations.hasValue(): self.ctfDict = {} for ctf in self.ctfRelations.get(): ctfName = ctf.getMicrograph().getMicName() self.ctfDict[ctfName] = self.getPreviousValues(ctf) if self.findPhaseShift and not self.ctfRelations.hasValue(): self._params['phaseShift0'] = 1.57079
def _defineCtfParamsDict(self): ProtCTFMicrographs._defineCtfParamsDict(self) if not hasattr(self, "ctfDict"): self.getPreviousParameters() self._createFilenameTemplates() self._program = 'xmipp_ctf_estimate_from_micrograph' # Mapping between base protocol parameters and the package specific # command options params = self.getCtfParamsDict() self.__params = {'kV': params['voltage'], 'Cs': params['sphericalAberration'], #'ctfmodelSize': params['windowSize'], 'Q0': params['ampContrast'], 'min_freq': params['lowRes'], 'max_freq': params['highRes'], #'pieceDim': params['windowSize'] } self._prepareArgs(self.__params) def _prepareRecalCommand(self, ctfModel): if self.recalculate: self._defineRecalValues(ctfModel) self._createFilenameTemplates() self._program = 'xmipp_ctf_estimate_from_psd_fast' self._args = "--psd %(psdFn)s " line = ctfModel.getObjComment().split() # get the size and the image of psd imgPsd = ctfModel.getPsdFile() psdFile = os.path.basename(imgPsd) imgh = ImageHandler() size, _, _, _ = imgh.getDimensions(imgPsd) mic = ctfModel.getMicrograph() micDir = self._getMicrographDir(mic) downFactor = self._calculateDownsampleList(mic.getSamplingRate())[0] params = dict(self.getCtfParamsDict()) params.update(self.getRecalCtfParamsDict()) # FIXME Where does this variable come from params.update({'psdFn': fnPsd, 'defocusU': float(line[0]) }) # Mapping between base protocol parameters and the package specific # command options self.__params = {'sampling_rate': params['samplingRate'], 'downSamplingPerformed': downFactor, 'kV': params['voltage'], 'Cs': params['sphericalAberration'], 'min_freq': line[3], 'max_freq': line[4], 'defocusU': params['defocusU'], 'Q0': params['ampContrast'], 'defocus_range': 5000, 'ctfmodelSize': size } if self.findPhaseShift: fnCTFparam = self._getFileName('ctfParam', micBase=self._getMicBase(mic)) mdCTFParam = md.MetaData(fnCTFparam) phase_shift = mdCTFParam.getValue(md.MDL_CTF_PHASE_SHIFT, mdCTFParam.firstObject()) self.__params['VPP_radius'] = 0.005 self.__params['phase_shift'] = phase_shift for par, val in self.__params.items(): self._args += " --%s %s" % (par, str(val)) def _setPsdFiles(self, ctfModel): micBase = self._getMicBase(ctfModel.getMicrograph()) extra = self._getExtraPath() def _getString(key): return String(self._getFileName(key, micBase=micBase, root=extra)) ctfModel._psdFile = _getString('psd') ctfModel._xmipp_enhanced_psd = _getString('enhanced_psd') ctfModel._xmipp_ctfmodel_quadrant = _getString('ctfmodel_quadrant') ctfModel._xmipp_ctfmodel_halfplane = _getString('ctfmodel_halfplane')
[docs] def evaluateSingleMicrograph(self, mic): micFn = mic.getFileName() micBase = self._getMicBase(mic) micDir = self._getMicrographDir(mic) def _getStr(key): return str(self._getFileName(key, micBase=micBase, root=micDir)) fnCTF = _getStr('ctfParam') mdCTFparam = md.MetaData(fnCTF) objId = mdCTFparam.firstObject() mdCTFparam.setValue(md.MDL_MICROGRAPH, micFn, objId) mdCTFparam.setValue(md.MDL_PSD, _getStr('psd'), objId) mdCTFparam.setValue(md.MDL_PSD_ENHANCED, _getStr('enhanced_psd'), objId) mdCTFparam.setValue(md.MDL_CTF_MODEL, _getStr('ctfParam'), objId) mdCTFparam.setValue(md.MDL_IMAGE1, _getStr('ctfmodel_quadrant'), objId) mdCTFparam.setValue(md.MDL_IMAGE2, _getStr('ctfmodel_halfplane'), objId) fnEval = _getStr('ctf') mdCTFparam.write(fnEval) # Evaluate if estimated ctf is good enough try: self.runJob("xmipp_ctf_sort_psds", "-i %s" % fnEval) except Exception: pass fnRejected = _getStr('rejected') # Check if it is a good PSD criterion = self._criterion_psd self.runJob("xmipp_metadata_utilities", '-i %s --query select "%s" -o %s' % (fnEval, criterion, fnRejected)) if not isMdEmpty(fnRejected): mdCTFparam = md.MetaData(fnEval) mdCTFparam.setValue(md.MDL_ENABLED, -1, mdCTFparam.firstObject()) mdCTFparam.write(fnEval) return False #Check if it is a good CTF estimation if self.findPhaseShift: criterion = self._criterion_phaseplate else: criterion = self._criterion_estimation self.runJob("xmipp_metadata_utilities", '-i %s --query select "%s" -o %s' % (fnEval, criterion, fnRejected)) retval = True if not isMdEmpty(fnRejected): retval = False mdCTFparam = md.MetaData(fnEval) mdCTFparam.setValue(md.MDL_ENABLED, -1, mdCTFparam.firstObject()) mdCTFparam.write(fnEval) """This method indicates which criteria is rejecting the estimated CTF""" if pwutils.envVarOn('SCIPION_DEBUG'): self.checkRejectedCriteria(fnEval, fnRejected) return retval
[docs] def checkRejectedCriteria(self, fnEval, fnRejected): self.runJob("xmipp_metadata_utilities", '-i %s --query select "ctfCritFirstZero<5" -o %s' % (fnEval, fnRejected)) if not isMdEmpty(fnRejected): print("Rejected ctfCritFirstZero<5") self.runJob("xmipp_metadata_utilities", '-i %s --query select "ctfCritMaxFreq>20" -o %s' % (fnEval, fnRejected)) if not isMdEmpty(fnRejected): print("Rejected ctfCritMaxFreq>20") self.runJob("xmipp_metadata_utilities", '-i %s --query select "ctfCritfirstZeroRatio<0.9" -o %s' % (fnEval, fnRejected)) if not isMdEmpty(fnRejected): print("Rejected ctfCritfirstZeroRatio<0.9") self.runJob("xmipp_metadata_utilities", '-i %s --query select "ctfCritfirstZeroRatio>1.1" -o %s' % (fnEval, fnRejected)) if not isMdEmpty(fnRejected): print("Rejected ctfCritfirstZeroRatio>1.1") self.runJob("xmipp_metadata_utilities", '-i %s --query select "ctfCritFirstMinFirstZeroRatio>10" -o %s' % (fnEval, fnRejected)) if not isMdEmpty(fnRejected): print("Rejected ctfCritFirstMinFirstZeroRatio>10") self.runJob("xmipp_metadata_utilities", '-i %s --query select "ctfCritCorr13<0.27" -o %s' % (fnEval, fnRejected)) if not isMdEmpty(fnRejected): print("Rejected ctfCritCorr13<0.27") self.runJob("xmipp_metadata_utilities", '-i %s --query select "ctfCritCtfMargin<1" -o %s' % (fnEval, fnRejected)) if not isMdEmpty(fnRejected): print("Rejected ctfCritCtfMargin<1") self.runJob("xmipp_metadata_utilities", '-i %s --query select "ctfCritNonAstigmaticValidty<0" -o %s' % (fnEval, fnRejected)) if not isMdEmpty(fnRejected): print("Rejected ctfCritNonAstigmaticValidty<0") self.runJob("xmipp_metadata_utilities", '-i %s --query select "ctfCritNonAstigmaticValidty>6.5" -o %s' % (fnEval, fnRejected)) if not isMdEmpty(fnRejected): print("Rejected ctfCritNonAstigmaticValidty>6.5") #self.runJob("xmipp_metadata_utilities", # '-i %s --query select "ctfBgGaussianSigmaU<1000" -o %s' # % (fnEval, fnRejected)) #if not isMdEmpty(fnRejected): # print("Rejected ctfBgGaussianSigmaU<1000") self.runJob("xmipp_metadata_utilities", '-i %s --query select "ctfCritIceness>1.03" -o %s' % (fnEval, fnRejected)) if not isMdEmpty(fnRejected): print("Rejected ctfCritIceness>1.03") self.runJob("xmipp_metadata_utilities", '-i %s --query select "ctfCritPsdCorr90<0.1" -o %s' % (fnEval, fnRejected)) if not isMdEmpty(fnRejected): print("Rejected ctfCritPsdCorr90<0.1")
def _createCtfModel(self, mic, updateSampling=True): if updateSampling: newSampling = mic.getSamplingRate() * self.ctfDownFactor.get() mic.setSamplingRate(newSampling) ctfParam = self._getFileName('ctf', micBase=self._getMicBase(mic), root=self._getExtraPath()) ctfModel2 = readCTFModel(ctfParam, mic) ctfModel2.setMicrograph(mic) self._setPsdFiles(ctfModel2) return ctfModel2 def _createErrorCtfParam(self, mic): ctfParam = self._getFileName('ctfErrorParam', micBase=self._getMicBase(mic), root=self._getExtraPath()) f = open(ctfParam, 'w+') lines = """# XMIPP_STAR_1 * # data_fullMicrograph _ctfSamplingRate -999 _ctfVoltage -999 _ctfDefocusU -999 _ctfDefocusV -999 _ctfDefocusAngle -999 _ctfSphericalAberration -999 _ctfChromaticAberration -999 _ctfEnergyLoss -999 _ctfLensStability -999 _ctfConvergenceCone -999 _ctfLongitudinalDisplacement -999 _ctfTransversalDisplacement -999 _ctfQ0 -999 _ctfK -999 _ctfEnvR0 -999 _ctfEnvR1 -999 _ctfEnvR2 -999 _ctfBgGaussianK -999 _ctfBgGaussianSigmaU -999 _ctfBgGaussianSigmaV -999 _ctfBgGaussianCU -999 _ctfBgGaussianCV -999 _ctfBgGaussianAngle -999 _ctfBgSqrtK -999 _ctfBgSqrtU -999 _ctfBgSqrtV -999 _ctfBgSqrtAngle -999 _ctfBgBaseline -999 _ctfBgGaussian2K -999 _ctfBgGaussian2SigmaU -999 _ctfBgGaussian2SigmaV -999 _ctfBgGaussian2CU -999 _ctfBgGaussian2CV -999 _ctfBgGaussian2Angle -999 _ctfBgR1 -999 _ctfBgR2 -999 _ctfBgR3 -999 _ctfX0 -999 _ctfXF -999 _ctfY0 -999 _ctfYF -999 _ctfCritFitting -999 _ctfCritCorr13 -999 _ctfVPPphaseshift -999 _ctfVPPRadius -999 _ctfCritIceness -999 _CtfDownsampleFactor -999 _ctfCritPsdStdQ -999 _ctfCritPsdPCA1 -999 _ctfCritPsdPCARuns -999 _micrograph NULL _psd NULL _psdEnhanced NULL _ctfModel NULL _image1 NULL _image2 NULL _enabled -1 _ctfCritFirstZero -999 _ctfCritMaxFreq -999 _ctfCritDamping -999 _ctfCritfirstZeroRatio -999 _ctfEnvelopePlot -999 _ctfCritFirstMinFirstZeroRatio -999 _ctfCritCtfMargin -999 _ctfCritNonAstigmaticValidty -999 _ctfCritPsdCorr90 -999 _ctfCritPsdInt -999 _ctfCritNormality -999 """ f.write(lines) f.close() return ctfParam def _getMicBase(self, mic): return pwutils.removeBaseExt(mic.getFileName())