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# *
# * Authors: Carlos Oscar Sorzano (info@kinestat.com)
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# * Kinestat Pharma
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import pyworkflow.protocol.params as params
from .protocol_pkpd_ode_base import ProtPKPDODEBase
from pkpd.models.pk_models import PK_TwocompartmentsClintCl
# TESTED in test_workflow_gabrielsson_pk18.py
# TESTED in test_workflow_ivivc2.py
[docs]class ProtPKPDTwoCompartmentsClintCl(ProtPKPDODEBase):
""" Fit a two-compartmentx model to a set of measurements (any arbitrary dosing regimen is allowed)\n
The central compartment is referred to as C, while the peripheral compartment as Cp.
The differential equation is V dC/dt = -(Clint+Clp+Cl) * C + Clp * Cp + dD/dt, Vp dCp/dt = Clp * C - Clp * Cp\n
and Clint=Vmax/(Km+C)\n
where C is the concentration of the central compartment, Cl the clearance, V and Vp the distribution volume of the central and peripheral compartment,\n
Clint is a saturated clearance\n
Clp is the distribution rate between the central and the peripheral compartments, \n
Vmax is the maximum processing capability of the metabolic pathway degrading the drug, \n
Km is the Michaelis-Menten constant,and D the input dosing regime. \n
Note that the intrinsic clearance occurs at the central volume.\n
Confidence intervals calculated by this fitting may be pessimistic because it assumes that all model parameters
are independent, which are not. Use Bootstrap estimates instead.\n
Protocol created by http://www.kinestatpharma.com\n"""
_label = 'pk two-compartments intrinsic+Cl'
def __init__(self,**kwargs):
ProtPKPDODEBase.__init__(self,**kwargs)
#--------------------------- DEFINE param functions --------------------------------------------
def _defineParams(self, form):
self._defineParams1(form, True, "t", "Cp")
form.addParam('bounds', params.StringParam, label="Parameter bounds ([tlag], sourceParameters, Vmax, Km, Cl, V, Clp, Vp)", default="",
help="Bounds for time delay, maximum processivity, Michaelis constant, clearance, volume and peripheral clearance and volume. "\
'Make sure that the bounds are expressed in the expected units (estimated from the sample itself).'\
'Be careful that Cl bounds must be given here. If you have an estimate of the elimination rate, this is Ke=Cl/V. Consequently, Cl=Ke*V ')
[docs] def createModel(self):
return PK_TwocompartmentsClintCl()