pkpd.protocols.protocol_pkpd_simulate_dose_escalation module¶

class pkpd.protocols.protocol_pkpd_simulate_dose_escalation.ProtPKPDSimulateDoseEscalation(**kwargs)[source]¶

Bases: pkpd.protocols.protocol_pkpd.ProtPKPD

Simulate a dose escalation

Protocol created by http://www.kinestatpharma.com

runSimulate(modelType, paramValues, reportX)[source]¶

pkpd.protocols.protocol_pkpd_simulate_dose_escalation.uniform(low=0.0, high=1.0, size=None)¶

Draw samples from a uniform distribution.

Samples are uniformly distributed over the half-open interval [low, high) (includes low, but excludes high). In other words, any value within the given interval is equally likely to be drawn by uniform.

Note

New code should use the uniform method of a default_rng() instance instead; see random-quick-start.

Parameters

low (float or array_like of floats, optional) – Lower boundary of the output interval. All values generated will be greater than or equal to low. The default value is 0.
high (float or array_like of floats) – Upper boundary of the output interval. All values generated will be less than high. The default value is 1.0.
size (int or tuple of ints, optional) – Output shape. If the given shape is, e.g., (m, n, k), then m * n * k samples are drawn. If size is None (default), a single value is returned if low and high are both scalars. Otherwise, np.broadcast(low, high).size samples are drawn.

Returns

out – Drawn samples from the parameterized uniform distribution.

Return type

ndarray or scalar

See also

randint: Discrete uniform distribution, yielding integers.
random_integers: Discrete uniform distribution over the closed interval [low, high].
random_sample: Floats uniformly distributed over [0, 1).
random: Alias for random_sample.
rand: Convenience function that accepts dimensions as input, e.g., rand(2,2) would generate a 2-by-2 array of floats, uniformly distributed over [0, 1).
Generator.uniform: which should be used for new code.

Notes

The probability density function of the uniform distribution is

p(x) = \frac{1}{b - a}

anywhere within the interval [a, b), and zero elsewhere.

When high == low, values of low will be returned. If high < low, the results are officially undefined and may eventually raise an error, i.e. do not rely on this function to behave when passed arguments satisfying that inequality condition.

Examples

Draw samples from the distribution:

>>> s = np.random.uniform(-1,0,1000)

All values are within the given interval:

>>> np.all(s >= -1)
True
>>> np.all(s < 0)
True

Display the histogram of the samples, along with the probability density function:

>>> import matplotlib.pyplot as plt
>>> count, bins, ignored = plt.hist(s, 15, density=True)
>>> plt.plot(bins, np.ones_like(bins), linewidth=2, color='r')
>>> plt.show()