pkpd.protocols.protocol_pkpd_bootstrap_simulate module

class pkpd.protocols.protocol_pkpd_bootstrap_simulate.ProtPKPDODESimulate(**kwargs)

Bases: pkpd.protocols.protocol_pkpd_ode_base.ProtPKPDODEBase

Simulate a population of ODE parameters. These parameters can be specifically given, from a bootstrap population, a previous fitting, or an experiment.

AUC0t and AUMC0t are referred to each dose (that is, t=0 is the beginning of the dose). Ctau is the concentration at the end of the dose.

Tmin, Tmax, and Ttau are referred to the beginning of the dose.

This protocol writes an Excel file (nca.xlsx) in which all the simulations and doses are written.

NCA(t, C)

PKTYPE_COMP1 = 0

PKTYPE_COMP2 = 1

PKTYPE_COMP2CLCLINT = 2

PRM_EXPERIMENT = 3

PRM_FITTING = 2

PRM_POPULATION = 0

PRM_USER_DEFINED = 1

SRC_LIST = 1

SRC_ODE = 0

VIATYPE_EV0 = 1

VIATYPE_EV1 = 2

VIATYPE_IV = 0

addSample(sampleName, doseName, simulationsX, y)

createOutputStep()

runSimulate(Nsimulations, confidenceInterval, doses)