pkpd.inhalation module¶

Classes for inhalation PK simulations.

See Hartung and Borghardt. A mechanistic framework for a priori pharmacokinetic predictions of orally inhaled drugs. PLOS Computational Biology, 16: e1008466 (2020)

class pkpd.inhalation.PKCiliarySpeed(**args)[source]¶

Bases: pwem.objects.data.EMObject

EXPON = 0¶

FIT = 1¶

INTERP = 2¶

prepare(lungParams, ciliarySpeedType)[source]¶

class pkpd.inhalation.PKDepositionParameters(**args)[source]¶

Bases: pwem.objects.data.EMObject

getData()[source]¶

read()[source]¶

readDepositionFile(alvlim)[source]¶

setFiles(fnSubstance, fnLung, fnDeposition)[source]¶

class pkpd.inhalation.PKInhalationDissolution(**args)[source]¶

Bases: pwem.objects.data.EMObject

CAP = 5¶

SAT = 2¶

TRUNC2_SAT = 4¶

TRUNC_SAT = 3¶

TRUNC_UNSAT = 1¶

UNSAT = 0¶

UNSOL = 7¶

XCAP = 6¶

getDissolution(s, Cf, h)[source]¶

prepare(substanceParams, part)[source]¶

class pkpd.inhalation.PKLung(**args)[source]¶

Bases: pwem.objects.data.EMObject

cilspeed(x)[source]¶

prepare(substanceParams, lungParams, pkParams, pkMultiplier, ciliarySpeedType)[source]¶

class pkpd.inhalation.PKPhysiologyLungParameters(**args)[source]¶

Bases: pwem.objects.data.EMObject

getAlveolar()[source]¶

getBronchial()[source]¶

getSystemic()[source]¶

read(fnIn)[source]¶

write(fnOut)[source]¶

class pkpd.inhalation.PKSubstanceLungParameters(**args)[source]¶

Bases: pwem.objects.data.EMObject

getData()[source]¶

read(fnIn)[source]¶

write(fnOut)[source]¶

pkpd.inhalation.P_Qbr(lungData, systemicData, Xbnd)[source]¶

pkpd.inhalation.P_aELF(lungData, Xbnd)[source]¶

pkpd.inhalation.P_aTis(lungData, Xbnd)[source]¶

pkpd.inhalation.P_hELF(lungData, Xctr)[source]¶

pkpd.inhalation.conserving_projection(X1, V1, X2)[source]¶

pkpd.inhalation.diam2vol(diameters)[source]¶

pkpd.inhalation.project_deposition_2D(depositionData, X, S, lungData)[source]¶

pkpd.inhalation.saturable_2D_upwind_IE(lungParams, pkLung, depositionParams, tt, Sbnd)[source]¶