pkpd.protocols.protocol_pkpd_monocompartment module

class pkpd.protocols.protocol_pkpd_monocompartment.ProtPKPDMonoCompartment(**kwargs)[source]

Bases: pkpd.protocols.protocol_pkpd_ode_base.ProtPKPDODEBase

Fit a monocompartmental model to a set of measurements obtained by oral doses (any arbitrary dosing regimen is allowed)

The differential equation is dC/dt = -Cl * C/V + 1/V * dD/dt

where C is the concentration, Cl the clearance, V the distribution volume, and D the input dosing regime.

Confidence intervals calculated by this fitting may be pessimistic because it assumes that all model parameters are independent, which are not. Use Bootstrap estimates instead.

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