pkpd.protocols.protocol_pkpd_monocompartment_clint module

class pkpd.protocols.protocol_pkpd_monocompartment_clint.ProtPKPDMonoCompartmentClint(**kwargs)[source]

Bases: pkpd.protocols.protocol_pkpd_ode_base.ProtPKPDODEBase

Fit a monocompartmental model to a set of measurements obtained by oral doses (any arbitrary dosing regimen is allowed)

The differential equation is dC/dt = -Clint * C/V + 1/V * dD/dt and Clint=Vmax/(Km+C)

where C is the concentration, Clint the intrinsic clearance, V the distribution volume, Vmax is the maximum

processing capability of the metabolic pathway degrading the drug, Km is the Michaelis-Menten constant,

and D the input dosing regime. Confidence intervals calculated by this fitting may be pessimistic because

it assumes that all model parameters are independent, which are not. Use Bootstrap estimates instead.

Protocol created by